《生命科学》 2010, 22(8): 811-815

抗HCV药物筛选系统研究进展

唐颖蕾，魏大巧，夏雪山

（昆明理工大学生命科学与技术学院，昆明650224）

摘　要：摘　要：丙型肝炎病毒(Hepatitis C virus， HCV) 感染的持久性引发慢性肝病疾病，并可能发展成为肝硬化和肝癌。目前对HCV的治疗不能达到理想的治疗效果，所以开发新型抗HCV药物迫在眉睫。抗HCV药物筛选的细胞模型，如复制子系统、假病毒系统、细胞培养系统，动物模型，如黑猩猩、uPA-SCID小鼠等，取得了快速的进展，并推动丙型肝炎的研究和抗HCV药物的发现。
关键词：HCV；复制子系统；HCV假病毒；HCV细胞培养系统；黑猩猩；uPA-SCID小鼠

Progress in evaluation systems of anti-HCV drugs

TANG Ying-lei， WEI Da-qiao， XIA Xue-shan*

(Faculty of Life Science and Technology， Kunming University of Science and Technology，Kunming 650224， China)

Abstract: Abstract: Hepatitis C virus (HCV) causes persistent infection and induces serious chronic hepatitis， liver cirrhosis， and ultimately hepatocellular. The current therapyies can not receive satisfactory results， so the development of new anti-HCV drugs is important. The cell models for drug screening， such as replicon system， HCV pseudotype particles， cell culture systems， and the animal model such as  chimpanzees and uPA-SCID mice， have made rapid progress， these progress will propel HCV research and the anti-HCV drug discovery.
Key words:  HCV; replicon system; HCV pseudotype particles; HCV cell culture; chimpanzees; uPA-SCID mice