《生命科学》 2010, 22(3): 291-295

白介素-1b在炎性痛中的作用及其机制

张文华，江剑平^*

(福建师范大学生命科学学院，福建省发育和神经生物学重点实验室，福州 350108)

摘　要：摘要：促炎细胞因子在许多病理状态下，如炎症、神经系统损伤、癌症等， 对疼痛和痛觉过敏的发生和维持有重要作用。目前得到普遍认可的促炎细胞因子有IL-1b、IL-6、TNF-a， 该文就IL-1b在炎性疼痛中的作用及其可能的外周、中枢机制作一综述。
关键词：白介素-1b；炎性痛；痛觉过敏

Roles and mechanisms of interleukin-1b during inflammatory pain

ZHANG Wen-hua， JIANG Jian-ping^*

(Key Laboratory of Developmental and Neurological Biology of Fujian Province， College of Life Sciences， Fujian Normal University， Fuzhou 350108， China)

Abstract: Abstract: Numerous studies have shown that pro-inflammatory cytokines induce or facilitate pain and hyperalgesia in the presence of inflammation， injury to the nervous system or cancer. At present， generally accepted pro-inflammatory cytokines are IL-1b， IL-6， TNF-a. This review outlines the recent findings of IL-1b in inflammatory pain and its possible peripheral and central mechanisms for the effects of IL-1b in nociceptive transmission.
Key words: interleukin-1b; inflammatory pain；hyperalgesia