《生命科学》 2010, 22(3): 272-277

Connexin 43在细胞死亡中的作用

宋东莉，刘晓宇，刘　雯，左　伋^*

(复旦大学上海医学院细胞与遗传医学系，上海200032)

摘　要：

摘　要：缝隙连接蛋白在细胞膜表面聚合形成半通道，部分两两结合构成缝隙连接通道，两者与胚胎发育、肿瘤发生及某些心脑血管疾病有关。Connexin 43 (Cx43) 在心肌细胞和神经细胞高表达，在多种缺血性心脑疾病及缺血再灌注损伤的病理过程中具有重要作用。近来有研究发现，Cx43也存在于线粒体和细胞核，分别参与心肌保护和细胞分化。该文以心肌细胞和神经细胞为主讨论近年来Cx 43在细胞死亡中的作用的研究进展。
关键词：Connexin 43；缝隙连接；半通道；细胞死亡；凋亡

Effects of Connexin 43 on cell death

SONG Dong-li， LIU Xiao-yu， LIU Wen， ZUO Ji^*

(Department of Cellular and Genetic Medicine， Shanghai Medical College， Fudan University， Shanghai 200032， China)

Abstract:

Abstract: Gap junction proterin， connexins， which oligomerize to form hemichannels or gap junction channels that dock to different membrane surfaces， plays an essential role in embryonic development， tumorigenesis， and progression of kinds of myocardial and mental disease. Connexin 43 (Cx43) is highly expressed in cardiomyocytes and neurocytes and involved in pathologic processes of ischemic conditions and ischemia-refusion. Recent studies show that Cx43 is located in mitochondria and nucleus.
Key words: Connexin 43; gap junction; hemichannel; cell death; apoptosis