《生命科学》 2010, 22(3): 262-266

MicroRNA与膀胱癌

王　刚

(浙江杭州市第一人民医院泌尿外科，杭州 310006)

摘　要：

摘　要：MicroRNA（miRNA）是一类21~23个核苷酸长度的单链非编码小分子RNA，在转录后水平调节基因表达，从而实现对组织发生、个体发育及肿瘤发生等生理病理过程的调节作用。膀胱癌是国人泌尿系统中最常见的肿瘤。研究表明，miRNA参与了膀胱癌的发生、发展，一些差异表达miRNA有望成为膀胱癌诊断、治疗的靶点。该文就miRNA在膀胱癌发病机理、诊断、治疗等方面的研究进展作一综述。
关键词：miRNA；膀胱癌；发病机理；诊断；治疗

MicroRNA and bladder cancer

WANG Gang

(Division of Urology and Genomics Laboratory， Hangzhou First People's Hospital， Hangzhou 310006， China)

Abstract:

Abstract: MicroRNAs (miRNAs) are 21-23nt regulatory， non-coding RNAs that are thought to control gene expression at the post transcriptional level. It was reported that miRNAs regulate a wide range of biological and pathological processes， including histogenesis， development and tumorigenesis. Bladder cancer is the most common urinary cancer in China. Growing evidences suggested that miRNAs were involved in the processes of bladder cancer carcinogenesis and progression. Some differential expressed miRNAs might serve as potential targets for bladder cancer diagnosis and treatment. This article reviews the current knowledge about the role of miRNAs in bladder cancer carcinogenesis， their potential role in improving diagnosis and therapeutics.
Key words: miRNA; bladder cancer; pathogenesis; diagnosis; treatment