《生命科学》 2010, 22(2): 169-172

逆转肾小管上皮细胞转分化的Smad信号转导机制

郝艳鹏，张 悦^*

（上海中医药大学科技实验中心，上海201203）

摘　要：

摘　要：肾小管上皮细胞转分化(tubular epithelial to menchymal transdifferentiation，EMT)是肾小管间质纤维化的重要病理机制之一。致纤维化细胞因子TGF-b通过几种信号转导途径调节EMT，其中TGF-b/Smads信号通路发挥核心作用。目前研究表明，Smad7、HGF、BMP-7等可通过调控Smads信号通路而逆转EMT，这为肾间质纤维化的防治提供了新的思路。该文主要介绍TGF-b/Smads信号通路在EMT发生的作用，以及Smad7、SnoN、HGF、BMP-7等分子是如何通过抑制Smads信号通路而发挥逆转EMT作用的。
关键词：肾小管上皮细胞；转分化；逆转；信号转导

The mechanisms of reversing tubular epithelial myofibroblast transdifferentiation by Smad signal transduction

HAO Yan-peng， ZHANG Yue^*

(Experiment Center for Science and Technology， Shanghai University of Traditional Chinese Medicine， Shanghai 201203， China)

Abstract:

Abstract: Tubular epithelial myofibroblast transdifferentiation (EMT) is an important pathomechanism of renal tubulointerstitial fibrosis. Transforming growth factor-b (TGF-b) is the most potent inducer that is capable of initiating and completing the entire EMT course by several signal transduction pathway， among which， TGF-b Smads is the most important one. Studies indicated that Smad7， SnoN， HGF， BMP-7 could reverse EMT by regulating Smads signal pathway， which represents a potential therapeutic approach to renal tubulointerstitial fibrosis. This review tries to interpret the role of TGF-b Smads signal pathway in EMT and the way through which Smad7、SnoN、HGF and BMP-7 reverse EMT by inhibiting Smads signal pathway.
Key words: renal tubular epithelial cell； transdiferentiation；reverse；signal transduction