《生命科学》 2010, 22(2): 139-142

microRNA-155研究进展

李　江，胡维新^*

(中南大学生物科学与技术学院分子生物研究中心，长沙 410078)

摘　要：

摘  要：microRNAs(miRNAs)是一类进化上保守的非编码单链小RNA，长19～24个核苷酸，能在转录后降解靶基因mRNA或抑制基因的翻译。microRNA-155(miR-155)具有多种生物学功能，它能影响造血细胞的分化，并在炎症反应、免疫反应中发挥重要作用。大量研究表明，miR-155在多种肿瘤细胞中过表达，推测其与肿瘤的发生发展密切相关。随着研究的深入，miR-155可能成为新的肿瘤标志物及肿瘤基因治疗的新靶点。
关键词：miR-155；造血细胞；炎症反应；免疫反应；肿瘤

The progress of microRNA-155 research

LI Jiang， HU Wei-xin^*

(Institute of Molecular Biology， School of Biological Science and Technology，Central South University， Changsha 410078， China)

Abstract:

Abstract: microRNAs (miRNAs) are a class of evolutionarily conserved， single-stranded， non-coding RNA molecules consisting of 19~24 nucleotides， which can degrade mRNA of target gene after transcription or suppress gene translation. Recently， miR-155 is proved as a typically multifunctional miRNA that influences the differentiation of hematopoietic cells， and plays an important biological role in inflammatory and immune response. A large number of studies have shown that miR-155 over-expresses in a lot kinds of tumor cells， suggesting it might be involved in the occurrence and development of tumors. We propose that miR-155 is likely to be a novel tumor marker and a potential application of tumor gene therapy.
Key words: miR-155; hematopoietic cells; inflammatory response; immune response; tumor