《生命科学》 2010, 22(2): 133-138

microRNA在肌肉发育中的功能研究进展

王星果^1，2，郁建锋¹，顾志良^1*

（1常熟理工学院生物科学与工程系，常熟 215500； 2苏州大学基础医学与生物科学学院，苏州 215123）

摘　要：

摘 要：microRNA (miRNA)是一类非编码的小RNA分子，它通过对靶mRNA的翻译抑制和降解对基因表达起负调节作用。现在人们已经清楚地知道miRNA参与了增殖、分化、凋亡、发育等许多生物过程。一些miRNA在肌肉中特异表达，参与肌肉发育。该文重点介绍了参与肌肉发育的miRNA。已有证据表明肌肉miRNA在肌肉的增殖和分化过程中起了重要的调节作用， miRNA的调节异常和肌肉疾病有关。因此，miRNA是一类新的肌肉调控因子，它有可能成为畜禽肉产量提高和肌肉相关疾病治疗的新型靶标。
关键词：miRNA；骨骼肌；心肌；发育

Function of microRNA in muscle development

WANG Xing-guo^1，2， YU Jian-feng¹， GU Zhi-liang^1*

(1 Department of Life Science and Technology， Changshu Institute of Technology， Changshu 215500， China; 2 College of Basic Medicine and Life Science， Soochow University， Suzhou 215123， China)

Abstract:

Abstract: microRNAs (miRNA)， a class of small noncoding RNAs， negatively regulate gene expression by translational repression and degradation of target mRNA. Now it has been clear that miRNAs are involved in many biological processes， including proliferation， differentiation， apoptosis and development. Some miRNAs are specifically expressed in muscle and involved in muscle development. In this review， we show the miRNAs involved in muscle development. There are evidences demonstrating that muscle miRNAs play an important role in regulating muscle proliferation and differentiation. Dysregulation of muscle miRNAs is related to muscle diseases. Therefore， miRNAs are a new class of regulators of muscle. They may become novel targets in optimization of muscle quantity of domestic animals and therapy of muscle related diseases.
Key words: miRNA; skeletal muscle; cardiac muscle; development